Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

BACKGROUND: Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau(294–305), an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau(294–305)-targeted approa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ji, Mei, Xie, Xi-xiu, Liu, Dong-qun, Yu, Xiao-lin, Zhang, Yue, Zhang, Ling-Xiao, Wang, Shao-wei, Huang, Ya-ru, Liu, Rui-tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006857/
https://www.ncbi.nlm.nih.gov/pubmed/29914543
http://dx.doi.org/10.1186/s13195-018-0378-7

Ejemplares similares

Ejemplares similares