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Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in APAP-induced liver injury. Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen spe...
Autores principales: | Yan, Mingzhu, Huo, Yazhen, Yin, Shutao, Hu, Hongbo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006912/ https://www.ncbi.nlm.nih.gov/pubmed/29753208 http://dx.doi.org/10.1016/j.redox.2018.04.019 |
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