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Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strain

BACKGROUND: Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-glycosylated polyene macrolide antibiotic with antifungal activity comparabl...

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Detalles Bibliográficos
Autores principales:	Yao, Tingting, Liu, Zengzhi, Li, Tong, Zhang, Hui, Liu, Jing, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006980/ https://www.ncbi.nlm.nih.gov/pubmed/29914489 http://dx.doi.org/10.1186/s12934-018-0943-6

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