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MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

BACKGROUND: Deletions of 6q15–16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functional...

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Detalles Bibliográficos
Autores principales:	Cordas dos Santos, David M., Eilers, Juliane, Sosa Vizcaino, Alfonso, Orlova, Elena, Zimmermann, Martin, Stanulla, Martin, Schrappe, Martin, Börner, Kathleen, Grimm, Dirk, Muckenthaler, Martina U., Kulozik, Andreas E., Kunz, Joachim B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006985/ https://www.ncbi.nlm.nih.gov/pubmed/29914415 http://dx.doi.org/10.1186/s12885-018-4525-0

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