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Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study

PURPOSE: Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction...

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Autores principales: Ohta, Masashi, Nakataki, Masahito, Takeda, Tomoya, Numata, Shusuke, Tominaga, Takeo, Kameoka, Naomi, Kubo, Hiroko, Kinoshita, Makoto, Matsuura, Kanae, Otomo, Maki, Takeichi, Naoya, Harada, Masafumi, Ohmori, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007191/
https://www.ncbi.nlm.nih.gov/pubmed/29942132
http://dx.doi.org/10.2147/NDT.S163132
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author Ohta, Masashi
Nakataki, Masahito
Takeda, Tomoya
Numata, Shusuke
Tominaga, Takeo
Kameoka, Naomi
Kubo, Hiroko
Kinoshita, Makoto
Matsuura, Kanae
Otomo, Maki
Takeichi, Naoya
Harada, Masafumi
Ohmori, Tetsuro
author_facet Ohta, Masashi
Nakataki, Masahito
Takeda, Tomoya
Numata, Shusuke
Tominaga, Takeo
Kameoka, Naomi
Kubo, Hiroko
Kinoshita, Makoto
Matsuura, Kanae
Otomo, Maki
Takeichi, Naoya
Harada, Masafumi
Ohmori, Tetsuro
author_sort Ohta, Masashi
collection PubMed
description PURPOSE: Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction in schizophrenia using structural equation modeling (SEM). PATIENTS AND METHODS: We performed a cross-sectional study of 21 patients with symptomatically stabilized schizophrenia and 21 age-, sex-, and education level-matched healthy controls who underwent resting-state functional magnetic resonance imaging. We evaluated SN dysfunction in schizophrenia using independent component analysis (ICA). We rated participant psychopathology using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Calgary Depression Scale for Schizophrenia (CDSS). We rated psychosocial aspect of subjective QOL using the Schizophrenia Quality of Life Scale (SQLS) psychosocial subscale. We applied SEM to examine the relationships between SN dysfunction, PANSS positive and negative scores, CDSS total scores, BACS composite scores, and SQLS psychosocial subscale scores. RESULTS: In second-level analysis after group ICA, patient group had significant lower right pallidum functional connectivity (FC) within the SN than the controls did (Montreal Neurological Institute [MNI] [x y z] = [22 −2 −6]) (p = 0.027, family-wise error [FWE] corrected). In SEM, we obtained a good fit for an SEM model in which SN dysfunction causes depressed mood, which in turn determines psychosocial aspect of subjective QOL (chi-squared p = 0.9, root mean square error of approximation (RMSEA) < 0.001, comparative fit index [CFI] = 1.00, and standardized root mean square residual [SRMR]= 0.020). CONCLUSION: We found a continuous process by which SN dysfunction causes depressed moods that determine psychosocial aspect of subjective QOL in schizophrenia. This is the first report that offers a unified explanation of functional neuroimaging, symptoms, and outcomes. Future studies combining neuroimaging techniques and clinical assessments would elucidate schizophrenia’s pathogenesis.
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spelling pubmed-60071912018-06-25 Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study Ohta, Masashi Nakataki, Masahito Takeda, Tomoya Numata, Shusuke Tominaga, Takeo Kameoka, Naomi Kubo, Hiroko Kinoshita, Makoto Matsuura, Kanae Otomo, Maki Takeichi, Naoya Harada, Masafumi Ohmori, Tetsuro Neuropsychiatr Dis Treat Original Research PURPOSE: Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction in schizophrenia using structural equation modeling (SEM). PATIENTS AND METHODS: We performed a cross-sectional study of 21 patients with symptomatically stabilized schizophrenia and 21 age-, sex-, and education level-matched healthy controls who underwent resting-state functional magnetic resonance imaging. We evaluated SN dysfunction in schizophrenia using independent component analysis (ICA). We rated participant psychopathology using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Calgary Depression Scale for Schizophrenia (CDSS). We rated psychosocial aspect of subjective QOL using the Schizophrenia Quality of Life Scale (SQLS) psychosocial subscale. We applied SEM to examine the relationships between SN dysfunction, PANSS positive and negative scores, CDSS total scores, BACS composite scores, and SQLS psychosocial subscale scores. RESULTS: In second-level analysis after group ICA, patient group had significant lower right pallidum functional connectivity (FC) within the SN than the controls did (Montreal Neurological Institute [MNI] [x y z] = [22 −2 −6]) (p = 0.027, family-wise error [FWE] corrected). In SEM, we obtained a good fit for an SEM model in which SN dysfunction causes depressed mood, which in turn determines psychosocial aspect of subjective QOL (chi-squared p = 0.9, root mean square error of approximation (RMSEA) < 0.001, comparative fit index [CFI] = 1.00, and standardized root mean square residual [SRMR]= 0.020). CONCLUSION: We found a continuous process by which SN dysfunction causes depressed moods that determine psychosocial aspect of subjective QOL in schizophrenia. This is the first report that offers a unified explanation of functional neuroimaging, symptoms, and outcomes. Future studies combining neuroimaging techniques and clinical assessments would elucidate schizophrenia’s pathogenesis. Dove Medical Press 2018-06-15 /pmc/articles/PMC6007191/ /pubmed/29942132 http://dx.doi.org/10.2147/NDT.S163132 Text en © 2018 Ohta et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ohta, Masashi
Nakataki, Masahito
Takeda, Tomoya
Numata, Shusuke
Tominaga, Takeo
Kameoka, Naomi
Kubo, Hiroko
Kinoshita, Makoto
Matsuura, Kanae
Otomo, Maki
Takeichi, Naoya
Harada, Masafumi
Ohmori, Tetsuro
Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title_full Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title_fullStr Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title_full_unstemmed Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title_short Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study
title_sort structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ica resting-state fmri study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007191/
https://www.ncbi.nlm.nih.gov/pubmed/29942132
http://dx.doi.org/10.2147/NDT.S163132
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