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Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study

BACKGROUND AND PURPOSE: Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investig...

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Autores principales: Dong, Wenhong, Pan, Xiong-Fei, Yu, Canqing, Lv, Jun, Guo, Yu, Bian, Zheng, Yang, Ling, Chen, Yiping, Wu, Tangchun, Chen, Zhengming, Pan, An, Li, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Stroke Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007294/
https://www.ncbi.nlm.nih.gov/pubmed/29886721
http://dx.doi.org/10.5853/jos.2017.01732
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author Dong, Wenhong
Pan, Xiong-Fei
Yu, Canqing
Lv, Jun
Guo, Yu
Bian, Zheng
Yang, Ling
Chen, Yiping
Wu, Tangchun
Chen, Zhengming
Pan, An
Li, Liming
author_facet Dong, Wenhong
Pan, Xiong-Fei
Yu, Canqing
Lv, Jun
Guo, Yu
Bian, Zheng
Yang, Ling
Chen, Yiping
Wu, Tangchun
Chen, Zhengming
Pan, An
Li, Liming
author_sort Dong, Wenhong
collection PubMed
description BACKGROUND AND PURPOSE: Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investigate the associations between SRH measures and risk of total and subtypes of stroke in Chinese population. METHODS: A total of 494,113 participants from the China Kadoorie Biobank without prior heart diseases or cancer (486,541 without stroke and 7,572 with stroke) were followed from baseline (2004 to 2008) until December 31, 2013. General and age-comparative SRH were obtained from baseline questionnaires. First-ever stroke or recurrent events were ascertained through linkage to disease registry system and health insurance data. RESULTS: We identified 27,662 first-ever stroke and 2,909 recurrent events during an average of 7.0 years of follow-up. Compared with excellent general SRH, the hazard ratios (HRs) and 95% confidence intervals (CIs) for first-ever stroke associated with good, fair, and poor general SRH were 1.04 (1.00 to 1.08), 1.19 (1.15 to 1.23), and 1.49 (1.42 to 1.56) in the multivariate model, respectively. Compared with better age-comparative SRH, the HRs (95% CIs) of same and worse age-comparative SRH were 1.13 (1.10 to 1.17) and 1.51 (1.45 to 1.58), respectively. The relations of SRH measures with ischemic stroke, hemorrhagic stroke, and recurrent stroke were similar to that with total first-ever stroke. However, the magnitude of associations was much stronger for fatal stroke than for non-fatal stroke. CONCLUSIONS: This large-scale prospective cohort suggests that self-perceived health status is associated with incident stroke, regardless of stroke subtype.
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spelling pubmed-60072942018-06-21 Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study Dong, Wenhong Pan, Xiong-Fei Yu, Canqing Lv, Jun Guo, Yu Bian, Zheng Yang, Ling Chen, Yiping Wu, Tangchun Chen, Zhengming Pan, An Li, Liming J Stroke Original Article BACKGROUND AND PURPOSE: Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investigate the associations between SRH measures and risk of total and subtypes of stroke in Chinese population. METHODS: A total of 494,113 participants from the China Kadoorie Biobank without prior heart diseases or cancer (486,541 without stroke and 7,572 with stroke) were followed from baseline (2004 to 2008) until December 31, 2013. General and age-comparative SRH were obtained from baseline questionnaires. First-ever stroke or recurrent events were ascertained through linkage to disease registry system and health insurance data. RESULTS: We identified 27,662 first-ever stroke and 2,909 recurrent events during an average of 7.0 years of follow-up. Compared with excellent general SRH, the hazard ratios (HRs) and 95% confidence intervals (CIs) for first-ever stroke associated with good, fair, and poor general SRH were 1.04 (1.00 to 1.08), 1.19 (1.15 to 1.23), and 1.49 (1.42 to 1.56) in the multivariate model, respectively. Compared with better age-comparative SRH, the HRs (95% CIs) of same and worse age-comparative SRH were 1.13 (1.10 to 1.17) and 1.51 (1.45 to 1.58), respectively. The relations of SRH measures with ischemic stroke, hemorrhagic stroke, and recurrent stroke were similar to that with total first-ever stroke. However, the magnitude of associations was much stronger for fatal stroke than for non-fatal stroke. CONCLUSIONS: This large-scale prospective cohort suggests that self-perceived health status is associated with incident stroke, regardless of stroke subtype. Korean Stroke Society 2018-05 2018-05-31 /pmc/articles/PMC6007294/ /pubmed/29886721 http://dx.doi.org/10.5853/jos.2017.01732 Text en Copyright © 2018 Korean Stroke Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dong, Wenhong
Pan, Xiong-Fei
Yu, Canqing
Lv, Jun
Guo, Yu
Bian, Zheng
Yang, Ling
Chen, Yiping
Wu, Tangchun
Chen, Zhengming
Pan, An
Li, Liming
Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title_full Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title_fullStr Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title_full_unstemmed Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title_short Self-Rated Health Status and Risk of Incident Stroke in 0.5 Million Chinese Adults: The China Kadoorie Biobank Study
title_sort self-rated health status and risk of incident stroke in 0.5 million chinese adults: the china kadoorie biobank study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007294/
https://www.ncbi.nlm.nih.gov/pubmed/29886721
http://dx.doi.org/10.5853/jos.2017.01732
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