IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are highly expressed during the cell-intrinsic immune response to viral infection. IFIT1 inhibits translation by binding directly to the 5′ end of foreign RNAs, particularly those with non-self cap structures, precluding the recruitm...

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Detalles Bibliográficos
Autores principales: Fleith, Renata C, Mears, Harriet V, Leong, Xin Yun, Sanford, Thomas J, Emmott, Edward, Graham, Stephen C, Mansur, Daniel S, Sweeney, Trevor R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007307/
https://www.ncbi.nlm.nih.gov/pubmed/29554348
http://dx.doi.org/10.1093/nar/gky191

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