The Uba4 domain interplay is mediated via a thioester that is critical for tRNA thiolation through Urm1 thiocarboxylation

Eukaryotic ubiquitin-like proteins (UBLs) have evolved from prokaryotic sulfur-carrier proteins (SCPs). Ubiquitin related modifier 1 (Urm1) shares biochemical and structural features of UBLs and SCPs and is essential for 2-thiolation of cytoplasmic tRNA. This chemical modification of wobble uridine...

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Detalles Bibliográficos
Autores principales: Termathe, Martin, Leidel, Sebastian A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007339/
https://www.ncbi.nlm.nih.gov/pubmed/29718331
http://dx.doi.org/10.1093/nar/gky312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007339/
https://www.ncbi.nlm.nih.gov/pubmed/29718331
http://dx.doi.org/10.1093/nar/gky312

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