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Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase

Thymine DNA glycosylase (TDG) excises thymine from mutagenic G·T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5−formylcytosine (fC) and 5−carboxylcytosine (caC), in a multistep pathway for DNA demethylation. TDG is modified by small ubiquitin-like mod...

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Detalles Bibliográficos
Autores principales:	Coey, Christopher T, Drohat, Alexander C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007377/ https://www.ncbi.nlm.nih.gov/pubmed/29660017 http://dx.doi.org/10.1093/nar/gky278

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