Performance of TEM-PCR vs Culture for Bacterial Identification in Pediatric Musculoskeletal Infections

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Improved diagnostics are needed for children with musculoskeletal infections (MSKIs). We assessed the performance of target-enriched multiplex polymerase chain reaction (TEM-PCR) in children with MSKI. TEM-PCR was concordant with culture in pathogen identification and antibiotic susceptibility testi...

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Detalles Bibliográficos
Autores principales: Wood, James B, Sesler, Cheryl, Stalons, Donald, Grigorenko, Elena, Schoenecker, Jonathan G, Creech, C Buddy, Thomsen, Isaac P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007387/
https://www.ncbi.nlm.nih.gov/pubmed/29977969
http://dx.doi.org/10.1093/ofid/ofy119
Descripción
Sumario:Improved diagnostics are needed for children with musculoskeletal infections (MSKIs). We assessed the performance of target-enriched multiplex polymerase chain reaction (TEM-PCR) in children with MSKI. TEM-PCR was concordant with culture in pathogen identification and antibiotic susceptibility testing, while increasing the overall yield of pathogen detection. This technology has the potential to inform judicious antimicrobial use early in the disease course.

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