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Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents
The long-term evolutionary history of many viral lineages is poorly understood. Novel sources of ancient DNA combined with phylogenetic analyses can provide insight into the time scale of virus evolution. Here we report viral sequences from ancient North American packrat middens. We screened samples...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007503/ https://www.ncbi.nlm.nih.gov/pubmed/29977605 http://dx.doi.org/10.1093/ve/vey014 |
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author | Larsen, Brendan B Cole, Kenneth L Worobey, Michael |
author_facet | Larsen, Brendan B Cole, Kenneth L Worobey, Michael |
author_sort | Larsen, Brendan B |
collection | PubMed |
description | The long-term evolutionary history of many viral lineages is poorly understood. Novel sources of ancient DNA combined with phylogenetic analyses can provide insight into the time scale of virus evolution. Here we report viral sequences from ancient North American packrat middens. We screened samples up to 27,000-years old and found evidence of papillomavirus (PV) infection in Neotoma cinerea (Bushy-tailed packrat). Phylogenetic analysis placed the PV sequences in a clade with other previously published PV sequences isolated from rodents. Concordance between the host and virus tree topologies along with a correlation in branch lengths suggests a shared evolutionary history between rodents and PVs. Based on host divergence times, PVs have likely been circulating in rodents for at least 17 million years. These results have implications for our understanding of PV evolution and for further research with ancient DNA from Neotoma middens. |
format | Online Article Text |
id | pubmed-6007503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60075032018-07-05 Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents Larsen, Brendan B Cole, Kenneth L Worobey, Michael Virus Evol Research Article The long-term evolutionary history of many viral lineages is poorly understood. Novel sources of ancient DNA combined with phylogenetic analyses can provide insight into the time scale of virus evolution. Here we report viral sequences from ancient North American packrat middens. We screened samples up to 27,000-years old and found evidence of papillomavirus (PV) infection in Neotoma cinerea (Bushy-tailed packrat). Phylogenetic analysis placed the PV sequences in a clade with other previously published PV sequences isolated from rodents. Concordance between the host and virus tree topologies along with a correlation in branch lengths suggests a shared evolutionary history between rodents and PVs. Based on host divergence times, PVs have likely been circulating in rodents for at least 17 million years. These results have implications for our understanding of PV evolution and for further research with ancient DNA from Neotoma middens. Oxford University Press 2018-06-15 /pmc/articles/PMC6007503/ /pubmed/29977605 http://dx.doi.org/10.1093/ve/vey014 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Larsen, Brendan B Cole, Kenneth L Worobey, Michael Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title | Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title_full | Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title_fullStr | Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title_full_unstemmed | Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title_short | Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
title_sort | ancient dna provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007503/ https://www.ncbi.nlm.nih.gov/pubmed/29977605 http://dx.doi.org/10.1093/ve/vey014 |
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