Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion

Cannabis is being increasingly used as a medical treatment for a variety of illnesses. However, the cannabis plant has more than 70 different phytocannabinoids with potential pharmacologic activity. Two of the most researched phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (...

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Autores principales: Boggs, Douglas Lee, Peckham, Alyssa, Boggs, Angela A., Ranganathan, Mohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: College of Psychiatric & Neurologic Pharmacists 2016
Materias:
The Pharmacodynamics of Medications Used in Psychiatric Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007535/
https://www.ncbi.nlm.nih.gov/pubmed/29955482
http://dx.doi.org/10.9740/mhc.2016.11.277
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author Boggs, Douglas Lee
Peckham, Alyssa
Boggs, Angela A.
Ranganathan, Mohini
author_facet Boggs, Douglas Lee
Peckham, Alyssa
Boggs, Angela A.
Ranganathan, Mohini
author_sort Boggs, Douglas Lee
collection PubMed
description Cannabis is being increasingly used as a medical treatment for a variety of illnesses. However, the cannabis plant has more than 70 different phytocannabinoids with potential pharmacologic activity. Two of the most researched phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Evidence suggests CBD can decrease some of the psychomimetic effects of THC. This has led to the development of a new drug, Nabiximols, for the treatment of moderate to severe spasticity due to multiple sclerosis. A discussion of evidence supporting proposed pharmacodynamic interplay between CBD and THC is presented.
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spelling pubmed-60075352018-06-28 Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion Boggs, Douglas Lee Peckham, Alyssa Boggs, Angela A. Ranganathan, Mohini Ment Health Clin The Pharmacodynamics of Medications Used in Psychiatric Disorders Cannabis is being increasingly used as a medical treatment for a variety of illnesses. However, the cannabis plant has more than 70 different phytocannabinoids with potential pharmacologic activity. Two of the most researched phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Evidence suggests CBD can decrease some of the psychomimetic effects of THC. This has led to the development of a new drug, Nabiximols, for the treatment of moderate to severe spasticity due to multiple sclerosis. A discussion of evidence supporting proposed pharmacodynamic interplay between CBD and THC is presented. College of Psychiatric & Neurologic Pharmacists 2016-11-03 /pmc/articles/PMC6007535/ /pubmed/29955482 http://dx.doi.org/10.9740/mhc.2016.11.277 Text en © 2016 CPNP. http://creativecommons.org/licenses/by-nc/3.0/ The Mental Health Clinician is a publication of the College of Psychiatric and Neurologic Pharmacists. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle The Pharmacodynamics of Medications Used in Psychiatric Disorders
Boggs, Douglas Lee
Peckham, Alyssa
Boggs, Angela A.
Ranganathan, Mohini
Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title_full Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title_fullStr Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title_full_unstemmed Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title_short Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
title_sort delta-9-tetrahydrocannabinol and cannabidiol: separating the chemicals from the “weed,” a pharmacodynamic discussion
topic The Pharmacodynamics of Medications Used in Psychiatric Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007535/
https://www.ncbi.nlm.nih.gov/pubmed/29955482
http://dx.doi.org/10.9740/mhc.2016.11.277
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