Cargando…
Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis
During hematopoiesis, red blood cells originate from the hematopoietic stem cell reservoir. Although the regulation of erythropoiesis and globin expression has been intensively investigated, the underlining mechanisms are not fully understood, including the interplay between transcription factors an...
Autores principales: | Kim, Min Young, Kim, Ji Sook, Son, Seung Han, Lim, Chang Su, Eum, Hea Young, Ha, Dae Hyun, Park, Mi Ae, Baek, Eun Jung, Ryu, Buom-Yong, Kang, Ho Chul, Uversky, Vladimir N, Kim, Chul Geun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007553/ https://www.ncbi.nlm.nih.gov/pubmed/29547954 http://dx.doi.org/10.1093/nar/gky193 |
Ejemplares similares
-
The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011) -
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
por: Günther, Katharina, et al.
Publicado: (2013) -
The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription
por: Yun, Won Ju, et al.
Publicado: (2014) -
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
por: Desai, Megha A., et al.
Publicado: (2015) -
Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)