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Mitochondrial Agents for Bipolar Disorder

BACKGROUND: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions...

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Autores principales: Pereira, Círia, Chavarria, Victor, Vian, João, Ashton, Melanie Maree, Berk, Michael, Marx, Wolfgang, Dean, Olivia May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007750/
https://www.ncbi.nlm.nih.gov/pubmed/29596661
http://dx.doi.org/10.1093/ijnp/pyy018
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author Pereira, Círia
Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
author_facet Pereira, Círia
Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
author_sort Pereira, Círia
collection PubMed
description BACKGROUND: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit. METHODS: This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder. A Clinicaltrials.gov and ANZCTR search was conducted for complete and ongoing trials on mitochondrial agents used in psychiatric disorders. A PubMed search was also conducted for literature published between January 1981 and July 2017. Systematic reviews, randomized controlled trials, observational studies, case series, and animal studies with an emphasis on agents affecting mitochondrial function and its role in bipolar disorder were included. The search was augmented by manually searching the references of key papers and related literature. The results were presented as a narrative review. RESULTS: Mitochondrial agents offer new horizons in mood disorder treatment. While some negative effects have been reported, most compounds are overall well tolerated and have generally benign side-effect profiles. CONCLUSIONS: The study of neuroinflammation, neurodegeneration, and mitochondrial function has contributed the understanding of bipolar disorder’s pathophysiology. Agents targeting these pathways could be a potential therapeutic strategy. Future directions include identification of novel candidate mitochondrial modulators as well as rigorous and well-powered clinical trials.
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spelling pubmed-60077502018-06-25 Mitochondrial Agents for Bipolar Disorder Pereira, Círia Chavarria, Victor Vian, João Ashton, Melanie Maree Berk, Michael Marx, Wolfgang Dean, Olivia May Int J Neuropsychopharmacol Review BACKGROUND: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit. METHODS: This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder. A Clinicaltrials.gov and ANZCTR search was conducted for complete and ongoing trials on mitochondrial agents used in psychiatric disorders. A PubMed search was also conducted for literature published between January 1981 and July 2017. Systematic reviews, randomized controlled trials, observational studies, case series, and animal studies with an emphasis on agents affecting mitochondrial function and its role in bipolar disorder were included. The search was augmented by manually searching the references of key papers and related literature. The results were presented as a narrative review. RESULTS: Mitochondrial agents offer new horizons in mood disorder treatment. While some negative effects have been reported, most compounds are overall well tolerated and have generally benign side-effect profiles. CONCLUSIONS: The study of neuroinflammation, neurodegeneration, and mitochondrial function has contributed the understanding of bipolar disorder’s pathophysiology. Agents targeting these pathways could be a potential therapeutic strategy. Future directions include identification of novel candidate mitochondrial modulators as well as rigorous and well-powered clinical trials. Oxford University Press 2018-03-27 /pmc/articles/PMC6007750/ /pubmed/29596661 http://dx.doi.org/10.1093/ijnp/pyy018 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Pereira, Círia
Chavarria, Victor
Vian, João
Ashton, Melanie Maree
Berk, Michael
Marx, Wolfgang
Dean, Olivia May
Mitochondrial Agents for Bipolar Disorder
title Mitochondrial Agents for Bipolar Disorder
title_full Mitochondrial Agents for Bipolar Disorder
title_fullStr Mitochondrial Agents for Bipolar Disorder
title_full_unstemmed Mitochondrial Agents for Bipolar Disorder
title_short Mitochondrial Agents for Bipolar Disorder
title_sort mitochondrial agents for bipolar disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007750/
https://www.ncbi.nlm.nih.gov/pubmed/29596661
http://dx.doi.org/10.1093/ijnp/pyy018
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