Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associate...

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Detalles Bibliográficos
Autores principales: Peterson, Tess E, Huppler Hullsiek, Katherine, Wyman Engen, Nicole, Kumarasamy, Nagalingeswaran, Lebech, Anne-Mette, Liappis, Angelike, Papadopoulos, Antonios, Polizzotto, Mark N, Schreiner, Pamela J, Duprez, Daniel, Baker, Jason V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007791/
https://www.ncbi.nlm.nih.gov/pubmed/29942822
http://dx.doi.org/10.1093/ofid/ofy117
Descripción
Sumario:We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

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