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Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease
We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associate...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007791/ https://www.ncbi.nlm.nih.gov/pubmed/29942822 http://dx.doi.org/10.1093/ofid/ofy117 |
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| author | Peterson, Tess E Huppler Hullsiek, Katherine Wyman Engen, Nicole Kumarasamy, Nagalingeswaran Lebech, Anne-Mette Liappis, Angelike Papadopoulos, Antonios Polizzotto, Mark N Schreiner, Pamela J Duprez, Daniel Baker, Jason V |
| author_facet | Peterson, Tess E Huppler Hullsiek, Katherine Wyman Engen, Nicole Kumarasamy, Nagalingeswaran Lebech, Anne-Mette Liappis, Angelike Papadopoulos, Antonios Polizzotto, Mark N Schreiner, Pamela J Duprez, Daniel Baker, Jason V |
| author_sort | Peterson, Tess E |
| collection | PubMed |
| description | We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease. |
| format | Online Article Text |
| id | pubmed-6007791 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60077912018-06-25 Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease Peterson, Tess E Huppler Hullsiek, Katherine Wyman Engen, Nicole Kumarasamy, Nagalingeswaran Lebech, Anne-Mette Liappis, Angelike Papadopoulos, Antonios Polizzotto, Mark N Schreiner, Pamela J Duprez, Daniel Baker, Jason V Open Forum Infect Dis Brief Report We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease. Oxford University Press 2018-05-19 /pmc/articles/PMC6007791/ /pubmed/29942822 http://dx.doi.org/10.1093/ofid/ofy117 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Peterson, Tess E Huppler Hullsiek, Katherine Wyman Engen, Nicole Kumarasamy, Nagalingeswaran Lebech, Anne-Mette Liappis, Angelike Papadopoulos, Antonios Polizzotto, Mark N Schreiner, Pamela J Duprez, Daniel Baker, Jason V Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title | Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title_full | Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title_fullStr | Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title_full_unstemmed | Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title_short | Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease |
| title_sort | inflammation associates with impaired small arterial elasticity early in hiv disease |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007791/ https://www.ncbi.nlm.nih.gov/pubmed/29942822 http://dx.doi.org/10.1093/ofid/ofy117 |
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