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Context-dependent expression of a conditionally-inducible form of active Akt

Akt kinases are key signaling components in proliferation-competent and post-mitotic cells. Here, we sought to create a conditionally-inducible form of active Akt for both in vitro and in vivo applications. We fused a ligand-responsive Destabilizing Domain (DD) derived from E. coli dihydrofolate red...

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Detalles Bibliográficos
Autores principales:	Park, Soyeon, Burke, Robert E., Kareva, Tatyana, Kholodilov, Nikolai, Aimé, Pascaline, Franke, Thomas F., Levy, Oren, Greene, Lloyd A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007834/ https://www.ncbi.nlm.nih.gov/pubmed/29920520 http://dx.doi.org/10.1371/journal.pone.0197899

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