A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load

Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; chemicals that inhibit efflux pumps may have potential for antibiotic development. Using an in-cell screen, we ident...

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Detalles Bibliográficos
Autores principales: Reens, Abigail L., Crooks, Amy L., Su, Chih-Chia, Nagy, Toni A., Reens, David L., Podoll, Jessica D., Edwards, Madeline E., Yu, Edward W., Detweiler, Corrella S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007937/
https://www.ncbi.nlm.nih.gov/pubmed/29879224
http://dx.doi.org/10.1371/journal.ppat.1007115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007937/
https://www.ncbi.nlm.nih.gov/pubmed/29879224
http://dx.doi.org/10.1371/journal.ppat.1007115

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