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Anti-cancer binary system activated by bacteriophage HK022 integrase

The binary system presented in this work is based on the bacteriophage HK022 integrase recombinase that activates the expression of a silenced Diphtheria toxin gene, both controlled by the cancer specific hTERT promoter. Using a lung cancer mice model, assays of different apoptotic and anti-apoptoti...

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Detalles Bibliográficos
Autores principales:	Elias, Amer, Gritsenko, Natasha, Gorovits, Rena, Spector, Itay, Prag, Gali, Yagil, Ezra, Kolot, Mikhail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007955/ https://www.ncbi.nlm.nih.gov/pubmed/29938000 http://dx.doi.org/10.18632/oncotarget.25512

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