Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

[Image: see text] There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs), enzymes that hydrolyze β-lactam antibiotics and confer resistance to Gram-negative bacteria. Here we present 6-phosphonomethylpyridine-2-carboxylates (PMPCs) as potent inhibitors of subclass B1 (...

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Detalles Bibliográficos
Autores principales: Hinchliffe, Philip, Tanner, Carol A., Krismanich, Anthony P., Labbé, Geneviève, Goodfellow, Valerie J., Marrone, Laura, Desoky, Ahmed Y., Calvopiña, Karina, Whittle, Emily E., Zeng, Fanxing, Avison, Matthew B., Bols, Niels C., Siemann, Stefan, Spencer, James, Dmitrienko, Gary I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007964/
https://www.ncbi.nlm.nih.gov/pubmed/29485857
http://dx.doi.org/10.1021/acs.biochem.7b01299

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