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Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo is still scarce. Here, we generated a Drosophila mode...

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Detalles Bibliográficos
Autores principales:	Cornelissen, Tom, Vilain, Sven, Vints, Katlijn, Gounko, Natalia, Verstreken, Patrik, Vandenberghe, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008047/ https://www.ncbi.nlm.nih.gov/pubmed/29809156 http://dx.doi.org/10.7554/eLife.35878

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