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Escape from homeostasis: spinal microcircuits and progression of amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), loss of motoneuron function leads to weakness and, ultimately, respiratory failure and death. Regardless of the initial pathogenic factors, motoneuron loss follows a specific pattern: the largest α-motoneurons die before smaller α-motoneurons, and γ-motoneuron...

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Detalles Bibliográficos
Autores principales: Brownstone, Robert M., Lancelin, Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008087/
https://www.ncbi.nlm.nih.gov/pubmed/29384454
http://dx.doi.org/10.1152/jn.00331.2017