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FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

BACKGROUND & AIMS: Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated mechanisms in neurons. In th...

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Detalles Bibliográficos
Autores principales:	McMillin, Matthew, Grant, Stephanie, Frampton, Gabriel, Petrescu, Anca D., Kain, Jessica, Williams, Elaina, Haines, Rebecca, Canady, Lauren, DeMorrow, Sharon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008252/ https://www.ncbi.nlm.nih.gov/pubmed/29928671 http://dx.doi.org/10.1016/j.jcmgh.2018.02.008

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