DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is...

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Detalles Bibliográficos
Autores principales: Kular, Lara, Liu, Yun, Ruhrmann, Sabrina, Zheleznyakova, Galina, Marabita, Francesco, Gomez-Cabrero, David, James, Tojo, Ewing, Ewoud, Lindén, Magdalena, Górnikiewicz, Bartosz, Aeinehband, Shahin, Stridh, Pernilla, Link, Jenny, Andlauer, Till F. M., Gasperi, Christiane, Wiendl, Heinz, Zipp, Frauke, Gold, Ralf, Tackenberg, Björn, Weber, Frank, Hemmer, Bernhard, Strauch, Konstantin, Heilmann-Heimbach, Stefanie, Rawal, Rajesh, Schminke, Ulf, Schmidt, Carsten O., Kacprowski, Tim, Franke, Andre, Laudes, Matthias, Dilthey, Alexander T., Celius, Elisabeth G., Søndergaard, Helle B., Tegnér, Jesper, Harbo, Hanne F., Oturai, Annette B., Olafsson, Sigurgeir, Eggertsson, Hannes P., Halldorsson, Bjarni V., Hjaltason, Haukur, Olafsson, Elias, Jonsdottir, Ingileif, Stefansson, Kari, Olsson, Tomas, Piehl, Fredrik, Ekström, Tomas J., Kockum, Ingrid, Feinberg, Andrew P., Jagodic, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008330/
https://www.ncbi.nlm.nih.gov/pubmed/29921915
http://dx.doi.org/10.1038/s41467-018-04732-5

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