Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role

Dysregulation of pre-mRNA alternative splicing (AS) is closely associated with cancers. However, the relationships between the AS and classic oncogenes/tumor suppressors are largely unknown. Here we show that the deletion of tumor suppressor PTEN alters pre-mRNA splicing in a phosphatase-independent...

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Detalles Bibliográficos
Autores principales: Shen, Shao-Ming, Ji, Yan, Zhang, Cheng, Dong, Shuang-Shu, Yang, Shuo, Xiong, Zhong, Ge, Meng-Kai, Yu, Yun, Xia, Li, Guo, Meng, Cheng, Jin-Ke, Liu, Jun-Ling, Yu, Jian-Xiu, Chen, Guo-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008332/
https://www.ncbi.nlm.nih.gov/pubmed/29921876
http://dx.doi.org/10.1038/s41467-018-04760-1

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