MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle

MicroRNAs (miRNA) are key modulators of gene expression and so act as putative fine-tuners of complex phenotypes. Here, we hypothesized that causal variants of complex traits are enriched in miRNAs and miRNA-target networks. First, we conducted a genome-wide association study (GWAS) for seven functi...

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Detalles Bibliográficos
Autores principales: Fang, Lingzhao, Sørensen, Peter, Sahana, Goutam, Panitz, Frank, Su, Guosheng, Zhang, Shengli, Yu, Ying, Li, Bingjie, Ma, Li, Liu, George, Lund, Mogens Sandø, Thomsen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008395/
https://www.ncbi.nlm.nih.gov/pubmed/29921979
http://dx.doi.org/10.1038/s41598-018-27729-y

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