Cargando…

NR3C1 hypermethylation in depressed and bullied adolescents

The disruption of key epigenetic processes during critical periods of brain development can increase an individual’s vulnerability to psychopathology later in life. For instance, DNA methylation in the glucocorticoid receptor gene (NR3C1) in adulthood is known to be associated with early-life advers...

Descripción completa

Detalles Bibliográficos
Autores principales: Efstathopoulos, Paschalis, Andersson, Filip, Melas, Philippe A., Yang, Liu L., Villaescusa, J. Carlos, Rȕegg, Joëlle, Ekström, Tomas J., Forsell, Yvonne, Galanti, Maria Rosaria, Lavebratt, Catharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008402/
https://www.ncbi.nlm.nih.gov/pubmed/29921868
http://dx.doi.org/10.1038/s41398-018-0169-8
_version_ 1783333166606450688
author Efstathopoulos, Paschalis
Andersson, Filip
Melas, Philippe A.
Yang, Liu L.
Villaescusa, J. Carlos
Rȕegg, Joëlle
Ekström, Tomas J.
Forsell, Yvonne
Galanti, Maria Rosaria
Lavebratt, Catharina
author_facet Efstathopoulos, Paschalis
Andersson, Filip
Melas, Philippe A.
Yang, Liu L.
Villaescusa, J. Carlos
Rȕegg, Joëlle
Ekström, Tomas J.
Forsell, Yvonne
Galanti, Maria Rosaria
Lavebratt, Catharina
author_sort Efstathopoulos, Paschalis
collection PubMed
description The disruption of key epigenetic processes during critical periods of brain development can increase an individual’s vulnerability to psychopathology later in life. For instance, DNA methylation in the glucocorticoid receptor gene (NR3C1) in adulthood is known to be associated with early-life adversities and has been suggested to mediate the development of stress-related disorders. However, the association between NR3C1 methylation and the emergence of internalizing symptoms in childhood and adolescence has not been studied extensively. In the present report, we used saliva DNA from a cohort of Swedish adolescents (13–14 years old; N = 1149) to measure NR3C1 methylation in the exon 1F region. Internalizing psychopathological symptoms were assessed using the Center for Epidemiologic Studies Depression Scale for Children (CES-DC). We found that NR3C1 hypermethylation was cross-sectionally associated with high score for internalizing symptoms in the whole group as well as among the female participants. In addition, an analysis of social environmental stressors revealed that reports of bullied or lacking friends were significantly associated with NR3C1 hypermethylation. This cross-sectional association of NR3C1 exon 1F hypermethylation with internalizing psychopathology in adolescents, as well as with bullying and lack of friends are novel results in this field. Longitudinal studies are needed to address whether NR3C1 methylation mediates the link between social stressors and psychopathology in adolescence.
format Online
Article
Text
id pubmed-6008402
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-60084022018-06-20 NR3C1 hypermethylation in depressed and bullied adolescents Efstathopoulos, Paschalis Andersson, Filip Melas, Philippe A. Yang, Liu L. Villaescusa, J. Carlos Rȕegg, Joëlle Ekström, Tomas J. Forsell, Yvonne Galanti, Maria Rosaria Lavebratt, Catharina Transl Psychiatry Article The disruption of key epigenetic processes during critical periods of brain development can increase an individual’s vulnerability to psychopathology later in life. For instance, DNA methylation in the glucocorticoid receptor gene (NR3C1) in adulthood is known to be associated with early-life adversities and has been suggested to mediate the development of stress-related disorders. However, the association between NR3C1 methylation and the emergence of internalizing symptoms in childhood and adolescence has not been studied extensively. In the present report, we used saliva DNA from a cohort of Swedish adolescents (13–14 years old; N = 1149) to measure NR3C1 methylation in the exon 1F region. Internalizing psychopathological symptoms were assessed using the Center for Epidemiologic Studies Depression Scale for Children (CES-DC). We found that NR3C1 hypermethylation was cross-sectionally associated with high score for internalizing symptoms in the whole group as well as among the female participants. In addition, an analysis of social environmental stressors revealed that reports of bullied or lacking friends were significantly associated with NR3C1 hypermethylation. This cross-sectional association of NR3C1 exon 1F hypermethylation with internalizing psychopathology in adolescents, as well as with bullying and lack of friends are novel results in this field. Longitudinal studies are needed to address whether NR3C1 methylation mediates the link between social stressors and psychopathology in adolescence. Nature Publishing Group UK 2018-06-19 /pmc/articles/PMC6008402/ /pubmed/29921868 http://dx.doi.org/10.1038/s41398-018-0169-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Efstathopoulos, Paschalis
Andersson, Filip
Melas, Philippe A.
Yang, Liu L.
Villaescusa, J. Carlos
Rȕegg, Joëlle
Ekström, Tomas J.
Forsell, Yvonne
Galanti, Maria Rosaria
Lavebratt, Catharina
NR3C1 hypermethylation in depressed and bullied adolescents
title NR3C1 hypermethylation in depressed and bullied adolescents
title_full NR3C1 hypermethylation in depressed and bullied adolescents
title_fullStr NR3C1 hypermethylation in depressed and bullied adolescents
title_full_unstemmed NR3C1 hypermethylation in depressed and bullied adolescents
title_short NR3C1 hypermethylation in depressed and bullied adolescents
title_sort nr3c1 hypermethylation in depressed and bullied adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008402/
https://www.ncbi.nlm.nih.gov/pubmed/29921868
http://dx.doi.org/10.1038/s41398-018-0169-8
work_keys_str_mv AT efstathopoulospaschalis nr3c1hypermethylationindepressedandbulliedadolescents
AT anderssonfilip nr3c1hypermethylationindepressedandbulliedadolescents
AT melasphilippea nr3c1hypermethylationindepressedandbulliedadolescents
AT yangliul nr3c1hypermethylationindepressedandbulliedadolescents
AT villaescusajcarlos nr3c1hypermethylationindepressedandbulliedadolescents
AT rueggjoelle nr3c1hypermethylationindepressedandbulliedadolescents
AT ekstromtomasj nr3c1hypermethylationindepressedandbulliedadolescents
AT forsellyvonne nr3c1hypermethylationindepressedandbulliedadolescents
AT galantimariarosaria nr3c1hypermethylationindepressedandbulliedadolescents
AT lavebrattcatharina nr3c1hypermethylationindepressedandbulliedadolescents