The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma

BACKGROUND: While lung adenocarcinoma patients can somewhat benefit from anti-angiogenic therapies, patients with squamous cell lung carcinoma (SQLC) cannot. The reasons for this discrepancy remain largely unknown. Soluble VEGF receptor-1, namely sVEGFR1-i13, is a truncated splice variant of the cel...

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Detalles Bibliográficos
Autores principales: Abou Faycal, Cherine, Brambilla, Elisabeth, Agorreta, Jackeline, Lepeltier, Nina, Jacquet, Thibault, Lemaître, Nicolas, Emadali, Anouk, Lucas, Anthony, Lacal, Pedro M, Montuenga, Luis, Pio, Ruben, Gazzeri, Sylvie, Eymin, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008445/
https://www.ncbi.nlm.nih.gov/pubmed/29795310
http://dx.doi.org/10.1038/s41416-018-0128-4

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