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V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions. Despite this apparent limitation in the antibody repertoire, high-affinity antibodies can be raised to a wide...

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Detalles Bibliográficos
Autores principales:	Leighton, Philip A., Morales, Jacqueline, Harriman, William D., Ching, Kathryn H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008532/ https://www.ncbi.nlm.nih.gov/pubmed/29951062 http://dx.doi.org/10.3389/fimmu.2018.01317

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