Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface

Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pul...

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Detalles Bibliográficos
Autores principales: Lin, Bijuan, Wu, Xuanjun, Zhao, Hu, Tian, Yunpeng, Han, Jiahuai, Liu, Jian, Han, Shoufa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008587/
https://www.ncbi.nlm.nih.gov/pubmed/29997860
http://dx.doi.org/10.1039/c5sc04133c
Descripción
Sumario:Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pulmonary metastasis and subcutaneous tumor growth of B16F10 melanoma cells in mice preimmunized to produce anti-DNP antibodies. Located on the exterior glycocalyx, (DNP)Sia is well-positioned to recruit antibodies. Given the high levels of natural anti-DNP antibodies in humans and ubiquitous sialylation across many cancers, (DNP)Sia offers a simplified route to redirect immunity against diverse tumors without recourse to preimmunization.

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