Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface

Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pul...

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Detalles Bibliográficos
Autores principales: Lin, Bijuan, Wu, Xuanjun, Zhao, Hu, Tian, Yunpeng, Han, Jiahuai, Liu, Jian, Han, Shoufa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008587/
https://www.ncbi.nlm.nih.gov/pubmed/29997860
http://dx.doi.org/10.1039/c5sc04133c
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author Lin, Bijuan
Wu, Xuanjun
Zhao, Hu
Tian, Yunpeng
Han, Jiahuai
Liu, Jian
Han, Shoufa
author_facet Lin, Bijuan
Wu, Xuanjun
Zhao, Hu
Tian, Yunpeng
Han, Jiahuai
Liu, Jian
Han, Shoufa
author_sort Lin, Bijuan
collection PubMed
description Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pulmonary metastasis and subcutaneous tumor growth of B16F10 melanoma cells in mice preimmunized to produce anti-DNP antibodies. Located on the exterior glycocalyx, (DNP)Sia is well-positioned to recruit antibodies. Given the high levels of natural anti-DNP antibodies in humans and ubiquitous sialylation across many cancers, (DNP)Sia offers a simplified route to redirect immunity against diverse tumors without recourse to preimmunization.
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spelling pubmed-60085872018-07-11 Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface Lin, Bijuan Wu, Xuanjun Zhao, Hu Tian, Yunpeng Han, Jiahuai Liu, Jian Han, Shoufa Chem Sci Chemistry Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pulmonary metastasis and subcutaneous tumor growth of B16F10 melanoma cells in mice preimmunized to produce anti-DNP antibodies. Located on the exterior glycocalyx, (DNP)Sia is well-positioned to recruit antibodies. Given the high levels of natural anti-DNP antibodies in humans and ubiquitous sialylation across many cancers, (DNP)Sia offers a simplified route to redirect immunity against diverse tumors without recourse to preimmunization. Royal Society of Chemistry 2016-06-01 2016-02-24 /pmc/articles/PMC6008587/ /pubmed/29997860 http://dx.doi.org/10.1039/c5sc04133c Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Lin, Bijuan
Wu, Xuanjun
Zhao, Hu
Tian, Yunpeng
Han, Jiahuai
Liu, Jian
Han, Shoufa
Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title_full Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title_fullStr Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title_full_unstemmed Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title_short Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
title_sort redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008587/
https://www.ncbi.nlm.nih.gov/pubmed/29997860
http://dx.doi.org/10.1039/c5sc04133c
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