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Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota

Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed betw...

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Autores principales: Xie, Yiqiang, Xiao, Man, Ni, Yali, Jiang, Shangfei, Feng, Guizhu, Sang, Shenggang, Du, Guankui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008625/
https://www.ncbi.nlm.nih.gov/pubmed/29967794
http://dx.doi.org/10.1155/2018/4230590
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author Xie, Yiqiang
Xiao, Man
Ni, Yali
Jiang, Shangfei
Feng, Guizhu
Sang, Shenggang
Du, Guankui
author_facet Xie, Yiqiang
Xiao, Man
Ni, Yali
Jiang, Shangfei
Feng, Guizhu
Sang, Shenggang
Du, Guankui
author_sort Xie, Yiqiang
collection PubMed
description Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H(2)O group. Compared with the db-/db-H(2)O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H(2)O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition.
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spelling pubmed-60086252018-07-02 Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota Xie, Yiqiang Xiao, Man Ni, Yali Jiang, Shangfei Feng, Guizhu Sang, Shenggang Du, Guankui J Diabetes Res Research Article Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H(2)O group. Compared with the db-/db-H(2)O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H(2)O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition. Hindawi 2018-06-04 /pmc/articles/PMC6008625/ /pubmed/29967794 http://dx.doi.org/10.1155/2018/4230590 Text en Copyright © 2018 Yiqiang Xie et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xie, Yiqiang
Xiao, Man
Ni, Yali
Jiang, Shangfei
Feng, Guizhu
Sang, Shenggang
Du, Guankui
Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title_full Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title_fullStr Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title_full_unstemmed Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title_short Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
title_sort alpinia oxyphylla miq. extract prevents diabetes in mice by modulating gut microbiota
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008625/
https://www.ncbi.nlm.nih.gov/pubmed/29967794
http://dx.doi.org/10.1155/2018/4230590
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