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Pregnancy Ketonemia and Development of the Fetal Central Nervous System
Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008755/ https://www.ncbi.nlm.nih.gov/pubmed/29971100 http://dx.doi.org/10.1155/2018/1242901 |
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author | Bronisz, Agata Ozorowski, Mateusz Hagner-Derengowska, Magdalena |
author_facet | Bronisz, Agata Ozorowski, Mateusz Hagner-Derengowska, Magdalena |
author_sort | Bronisz, Agata |
collection | PubMed |
description | Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones' effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development. |
format | Online Article Text |
id | pubmed-6008755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60087552018-07-03 Pregnancy Ketonemia and Development of the Fetal Central Nervous System Bronisz, Agata Ozorowski, Mateusz Hagner-Derengowska, Magdalena Int J Endocrinol Review Article Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones' effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development. Hindawi 2018-06-04 /pmc/articles/PMC6008755/ /pubmed/29971100 http://dx.doi.org/10.1155/2018/1242901 Text en Copyright © 2018 Agata Bronisz et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bronisz, Agata Ozorowski, Mateusz Hagner-Derengowska, Magdalena Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title_full | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title_fullStr | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title_full_unstemmed | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title_short | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
title_sort | pregnancy ketonemia and development of the fetal central nervous system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008755/ https://www.ncbi.nlm.nih.gov/pubmed/29971100 http://dx.doi.org/10.1155/2018/1242901 |
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