Cargando…

Pregnancy Ketonemia and Development of the Fetal Central Nervous System

Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Bronisz, Agata, Ozorowski, Mateusz, Hagner-Derengowska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008755/
https://www.ncbi.nlm.nih.gov/pubmed/29971100
http://dx.doi.org/10.1155/2018/1242901
_version_ 1783333243606532096
author Bronisz, Agata
Ozorowski, Mateusz
Hagner-Derengowska, Magdalena
author_facet Bronisz, Agata
Ozorowski, Mateusz
Hagner-Derengowska, Magdalena
author_sort Bronisz, Agata
collection PubMed
description Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones' effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development.
format Online
Article
Text
id pubmed-6008755
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60087552018-07-03 Pregnancy Ketonemia and Development of the Fetal Central Nervous System Bronisz, Agata Ozorowski, Mateusz Hagner-Derengowska, Magdalena Int J Endocrinol Review Article Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones' effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development. Hindawi 2018-06-04 /pmc/articles/PMC6008755/ /pubmed/29971100 http://dx.doi.org/10.1155/2018/1242901 Text en Copyright © 2018 Agata Bronisz et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bronisz, Agata
Ozorowski, Mateusz
Hagner-Derengowska, Magdalena
Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title_full Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title_fullStr Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title_full_unstemmed Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title_short Pregnancy Ketonemia and Development of the Fetal Central Nervous System
title_sort pregnancy ketonemia and development of the fetal central nervous system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008755/
https://www.ncbi.nlm.nih.gov/pubmed/29971100
http://dx.doi.org/10.1155/2018/1242901
work_keys_str_mv AT broniszagata pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem
AT ozorowskimateusz pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem
AT hagnerderengowskamagdalena pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem