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Dynamics and Thermodynamics of Transthyretin Association from Molecular Dynamics Simulations

Molecular dynamics simulations are used in this work to probe the structural stability and the dynamics of engineered mutants of transthyretin (TTR), i.e., the double mutant F87M/L110M (MT-TTR) and the triple mutant F87M/L110M/S117E (3M-TTR), in relation to wild-type. Free energy analysis from end-p...

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Detalles Bibliográficos
Autores principales:	Dongmo Foumthuim, Cedrix J., Corazza, Alessandra, Berni, Rodolfo, Esposito, Gennaro, Fogolari, Federico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008865/ https://www.ncbi.nlm.nih.gov/pubmed/29967786 http://dx.doi.org/10.1155/2018/7480749

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