Cargando…
Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin re...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008884/ https://www.ncbi.nlm.nih.gov/pubmed/29967787 http://dx.doi.org/10.1155/2018/8120263 |
_version_ | 1783333269034500096 |
---|---|
author | Cai, Zhen Liu, Hehe Wang, Liyun Li, Xinxin Bai, Lili Gan, Xinmeng Li, Liang Han, Chunchun |
author_facet | Cai, Zhen Liu, Hehe Wang, Liyun Li, Xinxin Bai, Lili Gan, Xinmeng Li, Liang Han, Chunchun |
author_sort | Cai, Zhen |
collection | PubMed |
description | Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin receptors. In our study, we adopt a comprehensive approach and various bioinformatics tools to analyse the evolution process of HCRTR gene family. It turns out that the second round of whole genome duplication in early vertebrate ancestry and the independent round in fish ancestry may contribute to the diversity of HCRTR gene family. HCRTR1 of fishes and mammals are not the same receptor, which means that there are three members in the family. HCRTR2 is proved to be the most ancient one in HCRTR gene family. After duplication events, the structure of HCRTR1 diverged from HCRTR2 owing to relaxed selective pressure. Negative selection is the predominant evolutionary force acting on the HCRTR gene family but HCRTR1 of mammals is found to be subjected to positive selection. Our study gains insight into the molecular evolution process of HCRTR gene family, which contributes to the further study of the system. |
format | Online Article Text |
id | pubmed-6008884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60088842018-07-02 Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates Cai, Zhen Liu, Hehe Wang, Liyun Li, Xinxin Bai, Lili Gan, Xinmeng Li, Liang Han, Chunchun Biomed Res Int Research Article Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin receptors. In our study, we adopt a comprehensive approach and various bioinformatics tools to analyse the evolution process of HCRTR gene family. It turns out that the second round of whole genome duplication in early vertebrate ancestry and the independent round in fish ancestry may contribute to the diversity of HCRTR gene family. HCRTR1 of fishes and mammals are not the same receptor, which means that there are three members in the family. HCRTR2 is proved to be the most ancient one in HCRTR gene family. After duplication events, the structure of HCRTR1 diverged from HCRTR2 owing to relaxed selective pressure. Negative selection is the predominant evolutionary force acting on the HCRTR gene family but HCRTR1 of mammals is found to be subjected to positive selection. Our study gains insight into the molecular evolution process of HCRTR gene family, which contributes to the further study of the system. Hindawi 2018-06-04 /pmc/articles/PMC6008884/ /pubmed/29967787 http://dx.doi.org/10.1155/2018/8120263 Text en Copyright © 2018 Zhen Cai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cai, Zhen Liu, Hehe Wang, Liyun Li, Xinxin Bai, Lili Gan, Xinmeng Li, Liang Han, Chunchun Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title | Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title_full | Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title_fullStr | Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title_full_unstemmed | Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title_short | Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates |
title_sort | molecular evolutionary analysis of the hcrtr gene family in vertebrates |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008884/ https://www.ncbi.nlm.nih.gov/pubmed/29967787 http://dx.doi.org/10.1155/2018/8120263 |
work_keys_str_mv | AT caizhen molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT liuhehe molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT wangliyun molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT lixinxin molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT bailili molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT ganxinmeng molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT liliang molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates AT hanchunchun molecularevolutionaryanalysisofthehcrtrgenefamilyinvertebrates |