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Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates

Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin re...

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Autores principales: Cai, Zhen, Liu, Hehe, Wang, Liyun, Li, Xinxin, Bai, Lili, Gan, Xinmeng, Li, Liang, Han, Chunchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008884/
https://www.ncbi.nlm.nih.gov/pubmed/29967787
http://dx.doi.org/10.1155/2018/8120263
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author Cai, Zhen
Liu, Hehe
Wang, Liyun
Li, Xinxin
Bai, Lili
Gan, Xinmeng
Li, Liang
Han, Chunchun
author_facet Cai, Zhen
Liu, Hehe
Wang, Liyun
Li, Xinxin
Bai, Lili
Gan, Xinmeng
Li, Liang
Han, Chunchun
author_sort Cai, Zhen
collection PubMed
description Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin receptors. In our study, we adopt a comprehensive approach and various bioinformatics tools to analyse the evolution process of HCRTR gene family. It turns out that the second round of whole genome duplication in early vertebrate ancestry and the independent round in fish ancestry may contribute to the diversity of HCRTR gene family. HCRTR1 of fishes and mammals are not the same receptor, which means that there are three members in the family. HCRTR2 is proved to be the most ancient one in HCRTR gene family. After duplication events, the structure of HCRTR1 diverged from HCRTR2 owing to relaxed selective pressure. Negative selection is the predominant evolutionary force acting on the HCRTR gene family but HCRTR1 of mammals is found to be subjected to positive selection. Our study gains insight into the molecular evolution process of HCRTR gene family, which contributes to the further study of the system.
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spelling pubmed-60088842018-07-02 Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates Cai, Zhen Liu, Hehe Wang, Liyun Li, Xinxin Bai, Lili Gan, Xinmeng Li, Liang Han, Chunchun Biomed Res Int Research Article Hypocretin system is composed of hypocretins (hcrts) and their receptors (hcrtrs), which has multiple vital functions. Hypocretins work via hypocretin receptors and it is reported that functional differentiation occurred in hcrtrs. It is necessary to figure out the evolution process of hypocretin receptors. In our study, we adopt a comprehensive approach and various bioinformatics tools to analyse the evolution process of HCRTR gene family. It turns out that the second round of whole genome duplication in early vertebrate ancestry and the independent round in fish ancestry may contribute to the diversity of HCRTR gene family. HCRTR1 of fishes and mammals are not the same receptor, which means that there are three members in the family. HCRTR2 is proved to be the most ancient one in HCRTR gene family. After duplication events, the structure of HCRTR1 diverged from HCRTR2 owing to relaxed selective pressure. Negative selection is the predominant evolutionary force acting on the HCRTR gene family but HCRTR1 of mammals is found to be subjected to positive selection. Our study gains insight into the molecular evolution process of HCRTR gene family, which contributes to the further study of the system. Hindawi 2018-06-04 /pmc/articles/PMC6008884/ /pubmed/29967787 http://dx.doi.org/10.1155/2018/8120263 Text en Copyright © 2018 Zhen Cai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cai, Zhen
Liu, Hehe
Wang, Liyun
Li, Xinxin
Bai, Lili
Gan, Xinmeng
Li, Liang
Han, Chunchun
Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title_full Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title_fullStr Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title_full_unstemmed Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title_short Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates
title_sort molecular evolutionary analysis of the hcrtr gene family in vertebrates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008884/
https://www.ncbi.nlm.nih.gov/pubmed/29967787
http://dx.doi.org/10.1155/2018/8120263
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