CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

BACKGROUND: The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a controversial role in different cancers, either as a tumor suppressor or a tumor promoter. To date, the exact function and underlying mechanism of CHIP in colorectal cancer (CRC) is not yet c...

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Detalles Bibliográficos
Autores principales: Xu, Jingjing, Zhou, Jun, Dai, Hanjue, Liu, Fei, Li, Wenjing, Wang, Wenjuan, Guo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008917/
https://www.ncbi.nlm.nih.gov/pubmed/29921293
http://dx.doi.org/10.1186/s12967-018-1540-5

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