The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review

The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiologi...

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Autores principales: Paci, Marine, Elkhatib, Razan, Longepied, Guy, Bourgeois, Patrice, Ray, Pierre F., Levy, Nicolas, Mitchell, Michael J., Metzler-Guillemain, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008938/
https://www.ncbi.nlm.nih.gov/pubmed/29946470
http://dx.doi.org/10.1186/s12610-018-0072-4
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author Paci, Marine
Elkhatib, Razan
Longepied, Guy
Bourgeois, Patrice
Ray, Pierre F.
Levy, Nicolas
Mitchell, Michael J.
Metzler-Guillemain, Catherine
author_facet Paci, Marine
Elkhatib, Razan
Longepied, Guy
Bourgeois, Patrice
Ray, Pierre F.
Levy, Nicolas
Mitchell, Michael J.
Metzler-Guillemain, Catherine
author_sort Paci, Marine
collection PubMed
description The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation during spermiogenesis. In this review, we summarize and discuss the data available in the literature regarding the involvement of lamins and their direct or indirect partners in normal and abnormal human spermiogenesis.
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spelling pubmed-60089382018-06-26 The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review Paci, Marine Elkhatib, Razan Longepied, Guy Bourgeois, Patrice Ray, Pierre F. Levy, Nicolas Mitchell, Michael J. Metzler-Guillemain, Catherine Basic Clin Androl Review Article The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation during spermiogenesis. In this review, we summarize and discuss the data available in the literature regarding the involvement of lamins and their direct or indirect partners in normal and abnormal human spermiogenesis. BioMed Central 2018-06-20 /pmc/articles/PMC6008938/ /pubmed/29946470 http://dx.doi.org/10.1186/s12610-018-0072-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Paci, Marine
Elkhatib, Razan
Longepied, Guy
Bourgeois, Patrice
Ray, Pierre F.
Levy, Nicolas
Mitchell, Michael J.
Metzler-Guillemain, Catherine
The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title_full The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title_fullStr The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title_full_unstemmed The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title_short The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
title_sort involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008938/
https://www.ncbi.nlm.nih.gov/pubmed/29946470
http://dx.doi.org/10.1186/s12610-018-0072-4
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