Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model

BACKGROUND & AIMS: Heavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic acini synthesize digestive enzymes (largely...

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Detalles Bibliográficos
Autores principales: Waldron, Richard T., Su, Hsin-Yuan, Piplani, Honit, Capri, Joseph, Cohn, Whitaker, Whitelegge, Julian P., Faull, Kym F., Sakkiah, Sugunadevi, Abrol, Ravinder, Yang, Wei, Zhou, Bo, Freeman, Michael R., Pandol, Stephen J., Lugea, Aurelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009017/
https://www.ncbi.nlm.nih.gov/pubmed/29930975
http://dx.doi.org/10.1016/j.jcmgh.2018.01.001

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