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Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot...

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Detalles Bibliográficos
Autores principales:	Sun, Jiyun, Zhen, Xiaohua, Ge, Huaibin, Zhang, Guangtao, An, Xuechan, Du, Yunfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009194/ https://www.ncbi.nlm.nih.gov/pubmed/29977409 http://dx.doi.org/10.3762/bjoc.14.123

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