Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

The system of the hypervalent iodine(III) reagent FPID and (4-MeOC(6)H(4))(3)P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was ob...

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Detalles Bibliográficos
Autores principales: Liu, Dan, Guo, Ya-Li, Qu, Jin, Zhang, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009197/
https://www.ncbi.nlm.nih.gov/pubmed/29977383
http://dx.doi.org/10.3762/bjoc.14.97
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author Liu, Dan
Guo, Ya-Li
Qu, Jin
Zhang, Chi
author_facet Liu, Dan
Guo, Ya-Li
Qu, Jin
Zhang, Chi
author_sort Liu, Dan
collection PubMed
description The system of the hypervalent iodine(III) reagent FPID and (4-MeOC(6)H(4))(3)P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.
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spelling pubmed-60091972018-07-05 Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis Liu, Dan Guo, Ya-Li Qu, Jin Zhang, Chi Beilstein J Org Chem Full Research Paper The system of the hypervalent iodine(III) reagent FPID and (4-MeOC(6)H(4))(3)P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction. Beilstein-Institut 2018-05-22 /pmc/articles/PMC6009197/ /pubmed/29977383 http://dx.doi.org/10.3762/bjoc.14.97 Text en Copyright © 2018, Liu et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Liu, Dan
Guo, Ya-Li
Qu, Jin
Zhang, Chi
Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title_full Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title_fullStr Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title_full_unstemmed Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title_short Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
title_sort recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009197/
https://www.ncbi.nlm.nih.gov/pubmed/29977383
http://dx.doi.org/10.3762/bjoc.14.97
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AT guoyali recyclablehypervalentiodinemediatedsolidphasepeptidesynthesisandcyclicpeptidesynthesis
AT qujin recyclablehypervalentiodinemediatedsolidphasepeptidesynthesisandcyclicpeptidesynthesis
AT zhangchi recyclablehypervalentiodinemediatedsolidphasepeptidesynthesisandcyclicpeptidesynthesis

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