Inteins in Microbial Genomes: Distribution, Mechanism, and Function

Inteins are self-splicing protein elements (134 to 608 amino acids). Over 125 inteins have been cataloged in InBase, the on-line intein database (http://www.neb.com/neb/inteins.html), which includes the Intein Registry[1]. Inteins naturally present in pathogenic microbes represent novel, yet unexplo...

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Detalles Bibliográficos
Autores principales: Southworth, Maurice W., Perler, Francine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2002
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009224/
https://www.ncbi.nlm.nih.gov/pubmed/29973787
http://dx.doi.org/10.1100/tsw.2002.13
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author Southworth, Maurice W.
Perler, Francine B.
author_facet Southworth, Maurice W.
Perler, Francine B.
author_sort Southworth, Maurice W.
collection PubMed
description Inteins are self-splicing protein elements (134 to 608 amino acids). Over 125 inteins have been cataloged in InBase, the on-line intein database (http://www.neb.com/neb/inteins.html), which includes the Intein Registry[1]. Inteins naturally present in pathogenic microbes represent novel, yet unexploited drug targets. Understanding the chemistry of the splicing reaction has allowed the manipulation of inteins, which are now used in many protein engineering applications[2].
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spelling pubmed-60092242018-07-04 Inteins in Microbial Genomes: Distribution, Mechanism, and Function Southworth, Maurice W. Perler, Francine B. ScientificWorldJournal Short Report Inteins are self-splicing protein elements (134 to 608 amino acids). Over 125 inteins have been cataloged in InBase, the on-line intein database (http://www.neb.com/neb/inteins.html), which includes the Intein Registry[1]. Inteins naturally present in pathogenic microbes represent novel, yet unexploited drug targets. Understanding the chemistry of the splicing reaction has allowed the manipulation of inteins, which are now used in many protein engineering applications[2]. TheScientificWorldJOURNAL 2002-05-29 /pmc/articles/PMC6009224/ /pubmed/29973787 http://dx.doi.org/10.1100/tsw.2002.13 Text en Copyright © 2002 Maurice W. Southworth and Francine B. Perler. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Southworth, Maurice W.
Perler, Francine B.
Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title_full Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title_fullStr Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title_full_unstemmed Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title_short Inteins in Microbial Genomes: Distribution, Mechanism, and Function
title_sort inteins in microbial genomes: distribution, mechanism, and function
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009224/
https://www.ncbi.nlm.nih.gov/pubmed/29973787
http://dx.doi.org/10.1100/tsw.2002.13
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