RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour reg...

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Detalles Bibliográficos
Autores principales: Mourtada-Maarabouni, Mirna, Williams, Gwyn T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2002
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009235/
https://www.ncbi.nlm.nih.gov/pubmed/12920317
http://dx.doi.org/10.1100/tsw.2002.859
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author Mourtada-Maarabouni, Mirna
Williams, Gwyn T.
author_facet Mourtada-Maarabouni, Mirna
Williams, Gwyn T.
author_sort Mourtada-Maarabouni, Mirna
collection PubMed
description The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.
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spelling pubmed-60092352018-07-04 RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? Mourtada-Maarabouni, Mirna Williams, Gwyn T. ScientificWorldJournal Review Article The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene. TheScientificWorldJOURNAL 2002-07-04 /pmc/articles/PMC6009235/ /pubmed/12920317 http://dx.doi.org/10.1100/tsw.2002.859 Text en Copyright © 2002 Mirna Mourtada-Maarabouni and Gwyn T. Williams. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mourtada-Maarabouni, Mirna
Williams, Gwyn T.
RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title_full RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title_fullStr RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title_full_unstemmed RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title_short RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
title_sort rbm5/luca-15 — tumour suppression by control of apoptosis and the cell cycle?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009235/
https://www.ncbi.nlm.nih.gov/pubmed/12920317
http://dx.doi.org/10.1100/tsw.2002.859
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