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Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture
A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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TheScientificWorldJOURNAL
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009254/ https://www.ncbi.nlm.nih.gov/pubmed/12806130 http://dx.doi.org/10.1100/tsw.2002.869 |
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author | Sherley, James L. |
author_facet | Sherley, James L. |
author_sort | Sherley, James L. |
collection | PubMed |
description | A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked reason for this difficulty may be the inherent asymmetric cell kinetics of stem cells in postnatal somatic tissues. Senescence is the expected fate of a culture whose growth depends on adult stem cells that divide with asymmetric cell kinetics. Therefore, the bioengineering of strategies to expand adult stem cells in culture requires knowledge of cellular mechanisms that control asymmetric cell kinetics. The properties of several genes recently implicated to function in a cellular pathway(s) that regulates asymmetric cell kinetics are discussed. Understanding the function of these genes in asymmetric cell kinetics mechanisms may be the key that unlocks the adult stem cell expansion problem. |
format | Online Article Text |
id | pubmed-6009254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-60092542018-07-04 Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture Sherley, James L. ScientificWorldJournal Review Article A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked reason for this difficulty may be the inherent asymmetric cell kinetics of stem cells in postnatal somatic tissues. Senescence is the expected fate of a culture whose growth depends on adult stem cells that divide with asymmetric cell kinetics. Therefore, the bioengineering of strategies to expand adult stem cells in culture requires knowledge of cellular mechanisms that control asymmetric cell kinetics. The properties of several genes recently implicated to function in a cellular pathway(s) that regulates asymmetric cell kinetics are discussed. Understanding the function of these genes in asymmetric cell kinetics mechanisms may be the key that unlocks the adult stem cell expansion problem. TheScientificWorldJOURNAL 2002-07-09 /pmc/articles/PMC6009254/ /pubmed/12806130 http://dx.doi.org/10.1100/tsw.2002.869 Text en Copyright © 2002 James L.Sherley. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sherley, James L. Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title_full | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title_fullStr | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title_full_unstemmed | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title_short | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
title_sort | asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009254/ https://www.ncbi.nlm.nih.gov/pubmed/12806130 http://dx.doi.org/10.1100/tsw.2002.869 |
work_keys_str_mv | AT sherleyjamesl asymmetriccellkineticsgenesthekeytoexpansionofadultstemcellsinculture |