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Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features

Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in orde...

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Autores principales: Petock, John M., Torshin, Ivan Y., Wang, Yuan-Fang, Du Bois, Garrett C., Croce, Carlo M., Harrison, Robert W., Weber, Irene T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009430/
https://www.ncbi.nlm.nih.gov/pubmed/12920316
http://dx.doi.org/10.1100/tsw.2002.826
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author Petock, John M.
Torshin, Ivan Y.
Wang, Yuan-Fang
Du Bois, Garrett C.
Croce, Carlo M.
Harrison, Robert W.
Weber, Irene T.
author_facet Petock, John M.
Torshin, Ivan Y.
Wang, Yuan-Fang
Du Bois, Garrett C.
Croce, Carlo M.
Harrison, Robert W.
Weber, Irene T.
author_sort Petock, John M.
collection PubMed
description Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. The tertiary structures of mouse Tcl1, human Tcl1, and Mtcp1 are very similar. Analysis of the structures revealed conserved semi-planar surfaces that have characteristics of surfaces involved in protein-protein interactions. The Tcl1 proteins show differences in surface charge distribution and oligomeric state suggesting that they do not interact in the same way with Akt/PKB and other cellular protein(s).
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spelling pubmed-60094302018-07-04 Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features Petock, John M. Torshin, Ivan Y. Wang, Yuan-Fang Du Bois, Garrett C. Croce, Carlo M. Harrison, Robert W. Weber, Irene T. ScientificWorldJournal Mini-Review Article Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. The tertiary structures of mouse Tcl1, human Tcl1, and Mtcp1 are very similar. Analysis of the structures revealed conserved semi-planar surfaces that have characteristics of surfaces involved in protein-protein interactions. The Tcl1 proteins show differences in surface charge distribution and oligomeric state suggesting that they do not interact in the same way with Akt/PKB and other cellular protein(s). TheScientificWorldJOURNAL 2002-07-04 /pmc/articles/PMC6009430/ /pubmed/12920316 http://dx.doi.org/10.1100/tsw.2002.826 Text en Copyright © 2002 John M. Petock et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Petock, John M.
Torshin, Ivan Y.
Wang, Yuan-Fang
Du Bois, Garrett C.
Croce, Carlo M.
Harrison, Robert W.
Weber, Irene T.
Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title_full Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title_fullStr Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title_full_unstemmed Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title_short Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
title_sort crystal structures of tcl1 family oncoproteins and their conserved surface features
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009430/
https://www.ncbi.nlm.nih.gov/pubmed/12920316
http://dx.doi.org/10.1100/tsw.2002.826
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