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Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging

We have developed a simple and versatile strategy for in situ growth of MnO(2) on the surfaces of oleic acid-capped hydrophobic upconversion nanoparticles (UCNPs) by optimizing the component concentrations in the Lemieux–von Rudloff reagent. The oxidation time was shortened by a factor of two compar...

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Autores principales: Wu, Yuan, Li, Dan, Zhou, Fang, Liang, Hao, Liu, Yuan, Hou, Weijia, Yuan, Quan, Zhang, Xiaobing, Tan, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009534/
https://www.ncbi.nlm.nih.gov/pubmed/30009014
http://dx.doi.org/10.1039/c8sc00490k
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author Wu, Yuan
Li, Dan
Zhou, Fang
Liang, Hao
Liu, Yuan
Hou, Weijia
Yuan, Quan
Zhang, Xiaobing
Tan, Weihong
author_facet Wu, Yuan
Li, Dan
Zhou, Fang
Liang, Hao
Liu, Yuan
Hou, Weijia
Yuan, Quan
Zhang, Xiaobing
Tan, Weihong
author_sort Wu, Yuan
collection PubMed
description We have developed a simple and versatile strategy for in situ growth of MnO(2) on the surfaces of oleic acid-capped hydrophobic upconversion nanoparticles (UCNPs) by optimizing the component concentrations in the Lemieux–von Rudloff reagent. The oxidation time was shortened by a factor of two compared to that of the reported method. This oxidation process has no obvious adverse effects on the phases of UCNPs. STEM, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and energy-dispersive X-ray analysis (EDX) characterization demonstrated the successful growth of MnO(2) on the surfaces of UCNPs. Furthermore, when the weight ratio of MnO(2)/UCNPs reached (147.61 ± 17.63) μg mg(–1), 50% of the initial upconversion luminescence of UCNPs was quenched, as revealed by fluorescence and inductively coupled plasma optical emission spectrometry (ICP-OES) results. The presence of the surface MnO(2) precipitate not only confers high dispersity of UCNPs in water, but also allows further activatable magnetic resonance imaging (MRI) and fluorescence multimodal imaging after reduction to Mn(2+) by intracellular glutathione (GSH). A novel targeted drug carrier nanosystem was prepared to protect MnO(2) from early decomposition in blood circulation by coating with mesoporous silica and capping with a gelatin nanolayer. Aptamer sgc8 was then attached to the surface of the gelatin nanolayer by covalent crosslinking to achieve targeted drug delivery. The results suggest that this nanosystem shows promise for further applications in cancer cell imaging and therapy.
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spelling pubmed-60095342018-07-13 Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging Wu, Yuan Li, Dan Zhou, Fang Liang, Hao Liu, Yuan Hou, Weijia Yuan, Quan Zhang, Xiaobing Tan, Weihong Chem Sci Chemistry We have developed a simple and versatile strategy for in situ growth of MnO(2) on the surfaces of oleic acid-capped hydrophobic upconversion nanoparticles (UCNPs) by optimizing the component concentrations in the Lemieux–von Rudloff reagent. The oxidation time was shortened by a factor of two compared to that of the reported method. This oxidation process has no obvious adverse effects on the phases of UCNPs. STEM, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and energy-dispersive X-ray analysis (EDX) characterization demonstrated the successful growth of MnO(2) on the surfaces of UCNPs. Furthermore, when the weight ratio of MnO(2)/UCNPs reached (147.61 ± 17.63) μg mg(–1), 50% of the initial upconversion luminescence of UCNPs was quenched, as revealed by fluorescence and inductively coupled plasma optical emission spectrometry (ICP-OES) results. The presence of the surface MnO(2) precipitate not only confers high dispersity of UCNPs in water, but also allows further activatable magnetic resonance imaging (MRI) and fluorescence multimodal imaging after reduction to Mn(2+) by intracellular glutathione (GSH). A novel targeted drug carrier nanosystem was prepared to protect MnO(2) from early decomposition in blood circulation by coating with mesoporous silica and capping with a gelatin nanolayer. Aptamer sgc8 was then attached to the surface of the gelatin nanolayer by covalent crosslinking to achieve targeted drug delivery. The results suggest that this nanosystem shows promise for further applications in cancer cell imaging and therapy. Royal Society of Chemistry 2018-05-17 /pmc/articles/PMC6009534/ /pubmed/30009014 http://dx.doi.org/10.1039/c8sc00490k Text en This journal is © The Royal Society of Chemistry 2018 https://creativecommons.org/licenses/by/3.0/This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Wu, Yuan
Li, Dan
Zhou, Fang
Liang, Hao
Liu, Yuan
Hou, Weijia
Yuan, Quan
Zhang, Xiaobing
Tan, Weihong
Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title_full Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title_fullStr Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title_full_unstemmed Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title_short Versatile in situ synthesis of MnO(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging
title_sort versatile in situ synthesis of mno(2) nanolayers on upconversion nanoparticles and their application in activatable fluorescence and mri imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009534/
https://www.ncbi.nlm.nih.gov/pubmed/30009014
http://dx.doi.org/10.1039/c8sc00490k
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