Cargando…

Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol

INTRODUCTION: Amoxicillin is the first-line antibiotic recommended by most scientific societies for the treatment of uncomplicated acute otitis media (AOM) in children and adults. In low-income and middle-income countries however, absence of setting-specific recommendations and antibiotic resistance...

Descripción completa

Detalles Bibliográficos
Autores principales: Choffor-Nchinda, Emmanuel, Atanga, Leonel Christophe, Nansseu, Jobert Richie, Djomou, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009545/
https://www.ncbi.nlm.nih.gov/pubmed/29884697
http://dx.doi.org/10.1136/bmjopen-2017-021133
_version_ 1783333410692923392
author Choffor-Nchinda, Emmanuel
Atanga, Leonel Christophe
Nansseu, Jobert Richie
Djomou, François
author_facet Choffor-Nchinda, Emmanuel
Atanga, Leonel Christophe
Nansseu, Jobert Richie
Djomou, François
author_sort Choffor-Nchinda, Emmanuel
collection PubMed
description INTRODUCTION: Amoxicillin is the first-line antibiotic recommended by most scientific societies for the treatment of uncomplicated acute otitis media (AOM) in children and adults. In low-income and middle-income countries however, absence of setting-specific recommendations and antibiotic resistance, promoted by higher population density and over-the-counter antibiotic availability, could hamper the effectiveness of amoxicillin. We aim to provide updated information to enable evidence-based decisions for first-line therapy of uncomplicated AOM in our setting. METHODS AND ANALYSIS: We will conduct a systematic review of all randomised controlled trials on the clinical effectiveness of amoxicillin for the treatment of uncomplicated AOM in children above 6 months and adults. The search will include studies published from the generation of the included databases to 31 December 2017. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and study quality will be assessed by the Risk of Bias Assessment Tool from the Cochrane Handbook for randomised trials. A meta-analysis will be conducted for homogeneous studies, eventually, using the fixed-effect model. Subgroup analysis will include age groups, amoxicillin dosage, treatment duration, effectiveness criteria, time of trial realisation, study quality and region of the world involved. ETHICS AND DISSEMINATION: Formal ethical approval is not required, as primary data will not be collected. The results will be disseminated through a peer-reviewed publication and presented at scientific meetings. PROSPERO REGISTRATION NUMBER: CRD42017080029.
format Online
Article
Text
id pubmed-6009545
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-60095452018-06-25 Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol Choffor-Nchinda, Emmanuel Atanga, Leonel Christophe Nansseu, Jobert Richie Djomou, François BMJ Open Ear, Nose and Throat/Otolaryngology INTRODUCTION: Amoxicillin is the first-line antibiotic recommended by most scientific societies for the treatment of uncomplicated acute otitis media (AOM) in children and adults. In low-income and middle-income countries however, absence of setting-specific recommendations and antibiotic resistance, promoted by higher population density and over-the-counter antibiotic availability, could hamper the effectiveness of amoxicillin. We aim to provide updated information to enable evidence-based decisions for first-line therapy of uncomplicated AOM in our setting. METHODS AND ANALYSIS: We will conduct a systematic review of all randomised controlled trials on the clinical effectiveness of amoxicillin for the treatment of uncomplicated AOM in children above 6 months and adults. The search will include studies published from the generation of the included databases to 31 December 2017. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and study quality will be assessed by the Risk of Bias Assessment Tool from the Cochrane Handbook for randomised trials. A meta-analysis will be conducted for homogeneous studies, eventually, using the fixed-effect model. Subgroup analysis will include age groups, amoxicillin dosage, treatment duration, effectiveness criteria, time of trial realisation, study quality and region of the world involved. ETHICS AND DISSEMINATION: Formal ethical approval is not required, as primary data will not be collected. The results will be disseminated through a peer-reviewed publication and presented at scientific meetings. PROSPERO REGISTRATION NUMBER: CRD42017080029. BMJ Publishing Group 2018-06-08 /pmc/articles/PMC6009545/ /pubmed/29884697 http://dx.doi.org/10.1136/bmjopen-2017-021133 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Ear, Nose and Throat/Otolaryngology
Choffor-Nchinda, Emmanuel
Atanga, Leonel Christophe
Nansseu, Jobert Richie
Djomou, François
Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title_full Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title_fullStr Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title_full_unstemmed Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title_short Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
title_sort effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol
topic Ear, Nose and Throat/Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009545/
https://www.ncbi.nlm.nih.gov/pubmed/29884697
http://dx.doi.org/10.1136/bmjopen-2017-021133
work_keys_str_mv AT choffornchindaemmanuel effectivenessofamoxicillinaloneinthetreatmentofuncomplicatedacuteotitismediaasystematicreviewprotocol
AT atangaleonelchristophe effectivenessofamoxicillinaloneinthetreatmentofuncomplicatedacuteotitismediaasystematicreviewprotocol
AT nansseujobertrichie effectivenessofamoxicillinaloneinthetreatmentofuncomplicatedacuteotitismediaasystematicreviewprotocol
AT djomoufrancois effectivenessofamoxicillinaloneinthetreatmentofuncomplicatedacuteotitismediaasystematicreviewprotocol