DeFine: deep convolutional neural networks accurately quantify intensities of transcription factor-DNA binding and facilitate evaluation of functional non-coding variants

The complex system of gene expression is regulated by the cell type-specific binding of transcription factors (TFs) to regulatory elements. Identifying variants that disrupt TF binding and lead to human diseases remains a great challenge. To address this, we implement sequence-based deep learning mo...

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Detalles Bibliográficos
Autores principales: Wang, Meng, Tai, Cheng, E, Weinan, Wei, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009584/
https://www.ncbi.nlm.nih.gov/pubmed/29617928
http://dx.doi.org/10.1093/nar/gky215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009584/
https://www.ncbi.nlm.nih.gov/pubmed/29617928
http://dx.doi.org/10.1093/nar/gky215

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