Cargando…

Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development

Little is known regarding how steroid hormone exposures impact the epigenetic landscape in a living organism. Here, we took a global approach to understanding how exposure to the estrogenic chemical, diethylstilbestrol (DES), affects the neonatal mouse uterine epigenome. Integration of RNA- and ChIP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jefferson, Wendy N, Kinyamu, H Karimi, Wang, Tianyuan, Miranda, Adam X, Padilla-Banks, Elizabeth, Suen, Alisa A, Williams, Carmen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009594/ https://www.ncbi.nlm.nih.gov/pubmed/29648668 http://dx.doi.org/10.1093/nar/gky260

Ejemplares similares

Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element
por: Vuilleumier, Robin, et al.
Publicado: (2019)

LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP
por: Bennesch, Marcela A., et al.
Publicado: (2016)

Regulatory sharing between estrogen receptor α bound enhancers
por: Carleton, Julia B, et al.
Publicado: (2020)

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
por: Shehreen, Saadlee, et al.
Publicado: (2022)

The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells
por: Xu, Beihui, et al.
Publicado: (2019)

A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria
por: Miguel-Arribas, Andrés, et al.
Publicado: (2021)

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage
por: Younger, Scott T., et al.
Publicado: (2015)

Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans
por: Reed, Kailee J, et al.
Publicado: (2020)

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene
por: Mitra, Partha, et al.
Publicado: (2012)

Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
por: Ji Yu, Eun, et al.
Publicado: (2011)

Estrogen receptor α can selectively repress dioxin receptor-mediated gene expression by targeting DNA methylation
por: Marques, Maud, et al.
Publicado: (2013)

Estrogen represses gene expression through reconfiguring chromatin structures
por: Osmanbeyoglu, Hatice Ulku, et al.
Publicado: (2013)

Estrogen-induced upregulation and 3′-UTR shortening of CDC6
por: Akman, Begum H., et al.
Publicado: (2012)

Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation
por: Sklias, Athena, et al.
Publicado: (2021)

Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities
por: Rennie, Sarah, et al.
Publicado: (2018)

The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes
por: Jangal, Maïka, et al.
Publicado: (2014)

Estrogen regulates divergent transcriptional and epigenetic cell states in breast cancer
por: Ors, Aysegul, et al.
Publicado: (2022)

KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
por: Gaughan, Luke, et al.
Publicado: (2013)

Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses
por: Bolt, Michael J., et al.
Publicado: (2013)

CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
por: Fiorito, Elisa, et al.
Publicado: (2016)

SIP1/NHERF2 enhances estrogen receptor alpha transactivation in breast cancer cells
por: Meneses-Morales, Ivan, et al.
Publicado: (2014)

Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor binding
por: Joshi, Sachindra R., et al.
Publicado: (2012)

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer
por: Wade, Mark A., et al.
Publicado: (2015)

Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alpha-associated long-range interactions
por: He, Chao, et al.
Publicado: (2014)

Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity
por: Stossi, Fabio, et al.
Publicado: (2020)

Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression
por: Jeong, Kwang Won, et al.
Publicado: (2014)

An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core subunits co-activates ERα action and associates with the sensitivity of antiestrogen in breast cancer
por: Sun, Ge, et al.
Publicado: (2020)

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation
por: Korkmaz, Gozde, et al.
Publicado: (2019)

The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation
por: Zhang, Yusheng, et al.
Publicado: (2021)

Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family
por: Lal, Sneha, et al.
Publicado: (2018)

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq
por: Glaser, Laura V, et al.
Publicado: (2021)

Chromatin condensation fluctuations rather than steady-state predict chromatin accessibility
por: Audugé, Nicolas, et al.
Publicado: (2019)

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites
por: Kulik, Marina, et al.
Publicado: (2021)

Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex
por: Gopalan, Sneha, et al.
Publicado: (2018)

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
por: Kozlenkov, Alexey, et al.
Publicado: (2014)

A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae
por: Rodríguez-Galán, Olga, et al.
Publicado: (2020)

Interaction of Glucocorticoid Receptor (GR) with Estrogen Receptor (ER) α and Activator Protein 1 (AP1) in Dexamethasone-mediated Interference of ERα Activity
por: Karmakar, Sudipan, et al.
Publicado: (2013)

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
por: Loughery, Jayne, et al.
Publicado: (2014)

Analysis of individual remodeled nucleosomes reveals decreased histone–DNA contacts created by hSWI/SNF
por: Bouazoune, Karim, et al.
Publicado: (2009)

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway
por: Bainbridge, Alex, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_imnlipgaqgbtp50ordt0pk0po8