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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended RNA off-targets by binding to partially complemen...

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Detalles Bibliográficos
Autores principales:	Hagedorn, Peter H, Pontoppidan, Malene, Bisgaard, Tina S, Berrera, Marco, Dieckmann, Andreas, Ebeling, Martin, Møller, Marianne R, Hudlebusch, Heidi, Jensen, Marianne L, Hansen, Henrik F, Koch, Troels, Lindow, Morten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009603/ https://www.ncbi.nlm.nih.gov/pubmed/29790953 http://dx.doi.org/10.1093/nar/gky397

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