PAPPA2 as a Therapeutic Modulator of IGF-I Bioavailability: in Vivo and in Vitro Evidence

CONTEXT: Pregnancy-associated plasma protein A2 (PAPPA2) is a protease that cleaves IGF-binding protein (IGFBP)-3 and IGFBP-5, liberating free IGF-I. Five patients from two families with genetic mutations in PAPPA2 presented with growth retardation, elevated total IGF-I, and IGFBP-3 but decreased fr...

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Detalles Bibliográficos
Autores principales: Andrew, Melissa, Liao, Lihong, Fujimoto, Masanobu, Khoury, Jane, Hwa, Vivian, Dauber, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2018
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009608/
https://www.ncbi.nlm.nih.gov/pubmed/29942928
http://dx.doi.org/10.1210/js.2018-00106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009608/
https://www.ncbi.nlm.nih.gov/pubmed/29942928
http://dx.doi.org/10.1210/js.2018-00106

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